WO2015029625

【特許番号】6335179
【登録日】2018年5月11日
【発明の名称】医療用具およびその製造方法
【出願日】2014年7月15日
【国際出願番号】JP2014068820
【国際公開番号】WO2015029625
【氏名又は名称】テルモ株式会社
＜Example 1＞
12 g of methyl vinyl ether maleic anhydride copolymer (trade name: GANTREZ AN-169 GAF)
85 g of ethanol
0.7 g of distilled water
refluxed at 78 °C. for 24 hours.

the reflux liquid, it was put in hexane,
the deposited precipitate was collected, dried at 70 ° C. under reduced pressure for 3 days

(ratio of the ester moiety in the structural unit derived from maleic acid) was 49%

A： (1) and (2)
B ： (3) )
degree of esterification = (B / 2 / A) × 100 (%)

0.25㎜Ni—Ti wire→ thermoplastic polyurethane resin→0.3 mm.

polyvinyl chloride (PVC) and 4,4′-diphenylmethane diisocyanate (MDI) in tetrahydrofuran (THF) (each concentration = 5% by weight) 25 ° Cー2 seconds

dried 　25 ° Cー30 minutes.
1% methyl vinyl ether-maleic acid copolymer (degree of esterification 49%)/THF 25℃ー1 second
60 ° Cー12 hours
pH 8.2ー60 ° C. 0.1% NaCl and 0.05% NaHCO 3
60 ° Cー1 minute
dried 25℃

＜Example 2＞
12 g methyl vinyl ether maleic anhydride copolymer (trade name: manufactured by GANTREZ AN-169 GAF)
83 g of ethanol
3.2 g of distilled water
refluxed for 24 hours
yield 11 g.

degree of esterification of the methyl vinyl ether-maleic acid copolymer obtained 46% (structural unit (a): structural unit ( b) molar ratio = 100: 8.7).
＜Example 3＞
12 g of methyl vinyl ether maleic anhydride copolymer (trade name: manufactured by GANTREZ AN-169 GAFF)
80 g of ethanol
6.3 g of distilled water
refluxed for 24 hours
yield 8 g
43%　structural unit (a): structural unit ( b) molar ratio = 100: 16.3
＜Example 4＞
12 g of methyl vinyl ether maleic anhydride copolymer (trade name: GANTREZ AN-169 GAF)
53 g of ethanol
41 g of distilled water
refluxed for 24 hours.

After cooling

put into diethyl ether
deposited precipitate was collected
dried at 70 ° C. under reduced pressure for 3 days

pulverizing
yield 8 g

35% (structural unit (a): structural unit ( b) molar ratio = 100: 42.9).

＜Comparative Example 1＞
same manner as in Example 1
degree of esterification of about 50%
＜Comparative Example 2＞
12 g of methyl vinyl ether maleic anhydride copolymer (trade name: manufactured by GANTREZ AN-169 GAF)
38 g of ethanol
60 g of distilled water
refluxed for 24 hours

yield 8 g

30%(structural unit (a): structural unit ( b) molar ratio = 100: 66.6).
＜Comparative Example 3＞
12 g of methyl vinyl ether maleic anhydride copolymer (trade name: GANTREZ AN-169 GAF)
85 g of ethanol
refluxed for 3.5 hours.
After cooling
put into hexane
deposited precipitate
dried at 70 ° C.3 days

yield 10 g

40%.
(Evaluation of swellability under normal environment)
in distilled water at 25 ° C. for 1 minute
the film thickness (μm) is measured with a microscope.
(Evaluation of swellability under severe conditions)
a temperature and humidity cycle test
swollen,
(Evaluation of surface lubricity)