Novel Guidewire Design and Coating for Continuous Delivery of Adenosine During Interventional Procedures

JAHA.120.019275 (ahajournals.org)

We developed a guidewire with spaced coils to increase surface area for drug loading. Guidewires were plasma treated to attach hydroxyl groups to metal surfaces, and a methoxy–polyethylene glycol–silanol primer layer was covalently linked to hydroxyl groups. Using polyvinyl alcohol, polyvinyl pyrrolidone, and polyvinyl acetate, a drug layer containing jet‐milled adenosine was hydrogen‐bonded to the polyethylene glycol–silanol layer and coated with an outer diffusive barrier layer.

Guidewires passed bench testing for lubricity, adherence, integrity, and tracking.

Follow me!