Basic Study on Anti-bacterial Urethral Catheter
Basic Study on Anti-bacterial Urethral Catheter
I. Development of a New Anti-bacterial Coating Material for Silicon Catheters
Hideaki HASHIMOTO, Noriaki ONO, Koichi MONDEN&Hiromi KUMON
Department of Urology, Okayama University School of Medicine
Tohru SHIBA, Toshiaki ADACHI&Kayo KANEKO
Create Medic, Technical Research Laboratory
In order to develop a new anti-bacterial urethral catheter, we studied anti-bacterial and antiadherent coating material suitable for silicon catheters. Several aspects of various silver compounds were examined, including anti-bacterial activity, chemical property and toxicity. Among silver citrate, silver phosphate and silver oxide, which were found to have excellent anti-bacterial activities,silver citrate was regarded as the material of choice for anti-bacterial coating in terms of durable activity and biological safety. It was also found that several surfactants inhibited bacterial adherence to the surface of silicon catheters. Among them soybean lecithin exhibited excellent anti-adherent activity in a dose dependent manner. Finally, a mixture of silver citrate, soybean lecithin and liquid silicon at the ratio of 2:2:8 was regarded as an ideal anti-bacterial coating materialfor silicon catheters
Basic Study on Anti-bacterial Urethral Catheter
II. Potency of a New Anti-bacterial Catheter and Its Durability in Experimental Models
Hideaki HASHIMOTO, Noriaki ONO, Koichi MONDEN&Hiromi KUMON
Department of Urology, Okayama University School of Medicine
Tohru SHIBA, Toshiaki ADACHI&Kayo KANEKO
Create Medic, Technical Research Laboratory
The potency and effectiveness of an anti-bacterial catheter coated with a mixture of silver citrate, soybean lecithin and liquid silicon at the ratio of 2:2:8 were compared withthose of commercially available anti-bacterial and conventional urethral catheters. This new anti-bacterial catheter
showed a strong activity and excellent durability in ordinary in vitro experimental studies. In the present series we have developed new in vitro experimental models for the evaluation of anti-bacterial catheters in inhibiting bacterial ascent via intraluminal or extraluminal route. The characteristic features of the silver citrate/lecithin catheter, namely strong activity and excellent durability, were confirmed using thes
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