ANTI-BACTERIAL POTENTIAL Toyoaki ZEOLITE BALLOON CATHETER FOR URINARY TRACT INFECTION

ANTI-BACTERIAL POTENTIAL Toyoaki ZEOLITE BALLOON CATHETER FOR URINARY TRACT INFECTION
抗菌性ゼオライトを含有した尿道バルーンカテーテルの抗菌効果とその応用

泌尿紀要381973-978,1992
(Acta Urol. Jpn. 38 973-978, 1992)

北里大学医学部泌尿器科学教室(主任:小柴健教授) 内田豊昭,丸典夫,古畑誠之,藤野淡人村本俊一,石橋晃,小柴健クリェートメデック技術研究所斯波徹,菊地哲也

1)抗菌ゼオライトカテーテルを試作し基礎的・臨床的にその効果について検討した.2)組織移植試験, 急性毒性試験, 発熱性物質試験, 溶血性試験において毒性は認められなかった.3)抗菌性試験では, 緑膿菌, 黄色ブドウ球菌, 大腸菌の順に抗菌性が認められ, その効果は抗菌ゼオライト含有濃度およびカテーテル面積に比例していた.4)長期留置例9例に最低3ヵ月間2～4週毎に本カテーテルを交換, 留置し, 従来型シリコーン製尿道バルーンカテーテルと交換前後の尿沈渣, 尿培養, 血算, 血液生化学, 自覚症状などについて比較検討した.5) UTI学会効果判定基準で9例中2例, 主治医判定9例中5例に効果が認められた
We present here a production of anti-bacterial zeolite balloon catheter and investigated its potential for controlling urinary tract infection. This anti-bacterial balloon catheter showed a bactericidal effect against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli in vitro studies. The antibacterial effects were correlated with the concentration of anti-bacterial zeolite and size of catheter. We tried this catheter for 11 various urological patients who needed a long-term indwelling of a balloon catheter for lower urinary tract obstruction and neurogenic bladder. All patients were already indwelled silicon balloon catheter for 3 to 6 months and suffered with complicated urinary tract infection. Nine patients who had this anti-bacterial zeolite balloon catheter indwelled for 3 to 7 months and exchanged every 2 to 4 weeks, and no patient was taking antibiotics during this trial. Two patients (22.2%) showed good results by the urinary tract infection (UTI) criteria and 5 patients (55.4%) showed good effects by doctor’s judgment. This anti-bacterial zeolite balloon catheter might be useful for patients who need long-term balloon catheter indwelling.