Silk as Biomaterials
バイオマテリアルとしてのシルク利用
玉 田 靖
Utilization of Silk as Biomaterials
Yasushi TAMADA (Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano 3868567, Japan)
Silk is fibrous protein material produced by silkworm and have been used as textile fiber with excellent luster,smooth texture, hygroscopicity, and mechanical strength. Recently silk has been studied as an advanced material used in various fields beyond textile fiber. Especially many papers are reported about silk material utilization as biomaterials used in medical fields based on the safety and biocompatibility from the fact which silk thread has been used as a surgical suture for long time. In this paper, a brief introduction concerning silk and silk proteins was described and then the safety and biocompatibility of silk materials were summarized from recent studies. And the utilization and
the functionalization of silk materials as biomaterials were introduced from our studies. And finally cartilage regeneration study used a silk fibroin sponge material as a scaffold was described on our recent results
日本ゴム協会誌 第87巻 第10号（2014）
オレオサイエンス 第20巻第12号（2020）
医療機器を指向したシルクフィブロイン素材開発に関する
研究動向 引用
※Around the year 2000, we conducted various medical evaluations and developed a biodegradable catheter. However, we decided to forgo commercialization, as the product was only evaluated in vitro and the price and market had not yet matured.Around this time, we also performed ion implantation on various materials to observe their biological responses.
As a method for producing a high molecular weight silk fibroin aqueous solution, it is common to refine raw materials such as waste cocoons and raw silk, dissolve them in a high-concentration neutral salt solution, and then desalinate using methods such as dialysis or ultrafiltration. Preparing the raw materials is quite labor-intensive.
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