血液とふれても血栓をつくらない材料についてーミクロ不均質表層構造ー
Materials that do not form blood clots even when in contact with blood – Microheterogeneous surface structure –
In conclusion, it seems advantageous to have a suitably heterogeneous surface structure with micro-irregularities in the range of 0 to 2 micrometers, rather than being overly smooth and homogeneous or excessively heterogeneous. Here, ‘heterogeneous’ includes the presence of irregularities and refers to the random distribution of materials with different properties.
So far, there has been no mention of how blood clots form or their properties. However, in a state where blood is moving, preventing the adhesion of blood cells is an important point for thrombosis prevention. Considering the interaction between the surface and platelets of 2-3 micrometers, red blood cells of 8 micrometers, and even larger white blood cells, it can be imagined that a suitably heterogeneous surface would reduce interactions, making adhesion less likely。
Yohji IMAI 今井庸二 東京医科歯科大学
※I synthesized urethane myself, confirmed the AFM images, and evaluated them.
Follow me!
